                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
 
<120>  Methods For Treating Pressure Induced Optic Neuropathy, 
       Preventing Neuronal Degeneration And Promoting Neuronal Cell 
       Survival Via Administration Of Lingo-1 Antagonists And Trkb 
       Agonists

<130>  2159.173PC01/EJH/CLD 

<140>  To Be Assigned
<141>  2008-10-10

<150>  60/979,338
<151>  2007-10-11

<160>  34    

<170>  PatentIn version 3.3

<210>  1
<211>  1845
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctggcgg ggggcgtgag gagcatgccc agccccctcc tggcctgctg gcagcccatc     60

ctcctgctgg tgctgggctc agtgctgtca ggctcggcca cgggctgccc gccccgctgc    120

gagtgctccg cccaggaccg cgctgtgctg tgccaccgca agcgctttgt ggcagtcccc    180

gagggcatcc ccaccgagac gcgcctgctg gacctaggca agaaccgcat caaaacgctc    240

aaccaggacg agttcgccag cttcccgcac ctggaggagc tggagctcaa cgagaacatc    300

gtgagcgccg tggagcccgg cgccttcaac aacctcttca acctccggac gctgggtctc    360

cgcagcaacc gcctgaagct catcccgcta ggcgtcttca ctggcctcag caacctgacc    420

aagctggaca tcagcgagaa caagattgtt atcctgctgg actacatgtt tcaggacctg    480

tacaacctca agtcactgga ggttggcgac aatgacctcg tctacatctc tcaccgcgcc    540

ttcagcggcc tcaacagcct ggagcagctg acgctggaga aatgcaacct gacctccatc    600

cccaccgagg cgctgtccca cctgcacggc ctcatcgtcc tgaggctccg gcacctcaac    660

atcaatgcca tccgggacta ctccttcaag aggctctacc gactcaaggt cttggagatc    720

tcccactggc cctacttgga caccatgaca cccaactgcc tctacggcct caacctgacg    780

tccctgtcca tcacacactg caatctgacc gctgtgccct acctggccgt ccgccaccta    840

gtctatctcc gcttcctcaa cctctcctac aaccccatca gcaccattga gggctccatg    900

ttgcatgagc tgctccggct gcaggagatc cagctggtgg gcgggcagct ggccgtggtg    960

gagccctatg ccttccgcgg cctcaactac ctgcgcgtgc tcaatgtctc tggcaaccag   1020

ctgaccacac tggaggaatc agtcttccac tcggtgggca acctggagac actcatcctg   1080

gactccaacc cgctggcctg cgactgtcgg ctcctgtggg tgttccggcg ccgctggcgg   1140

ctcaacttca accggcagca gcccacgtgc gccacgcccg agtttgtcca gggcaaggag   1200

ttcaaggact tccctgatgt gctactgccc aactacttca cctgccgccg cgcccgcatc   1260

cgggaccgca aggcccagca ggtgtttgtg gacgagggcc acacggtgca gtttgtgtgc   1320

cgggccgatg gcgacccgcc gcccgccatc ctctggctct caccccgaaa gcacctggtc   1380

tcagccaaga gcaatgggcg gctcacagtc ttccctgatg gcacgctgga ggtgcgctac   1440

gcccaggtac aggacaacgg cacgtacctg tgcatcgcgg ccaacgcggg cggcaacgac   1500

tccatgcccg cccacctgca tgtgcgcagc tactcgcccg actggcccca tcagcccaac   1560

aagaccttcg ctttcatctc caaccagccg ggcgagggag aggccaacag cacccgcgcc   1620

actgtgcctt tccccttcga catcaagacc ctcatcatcg ccaccaccat gggcttcatc   1680

tctttcctgg gcgtcgtcct cttctgcctg gtgctgctgt ttctctggag ccggggcaag   1740

ggcaacacaa agcacaacat cgagatcgag tatgtgcccc gaaagtcgga cgcaggcatc   1800

agctccgccg acgcgccccg caagttcaac atgaagatga tatga                   1845 


<210>  2
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Ala Gly Gly Val Arg Ser Met Pro Ser Pro Leu Leu Ala Cys 
1               5                   10                  15      


Trp Gln Pro Ile Leu Leu Leu Val Leu Gly Ser Val Leu Ser Gly Ser 
            20                  25                  30          


Ala Thr Gly Cys Pro Pro Arg Cys Glu Cys Ser Ala Gln Asp Arg Ala 
        35                  40                  45              


Val Leu Cys His Arg Lys Arg Phe Val Ala Val Pro Glu Gly Ile Pro 
    50                  55                  60                  


Thr Glu Thr Arg Leu Leu Asp Leu Gly Lys Asn Arg Ile Lys Thr Leu 
65                  70                  75                  80  


Asn Gln Asp Glu Phe Ala Ser Phe Pro His Leu Glu Glu Leu Glu Leu 
                85                  90                  95      


Asn Glu Asn Ile Val Ser Ala Val Glu Pro Gly Ala Phe Asn Asn Leu 
            100                 105                 110         


Phe Asn Leu Arg Thr Leu Gly Leu Arg Ser Asn Arg Leu Lys Leu Ile 
        115                 120                 125             


Pro Leu Gly Val Phe Thr Gly Leu Ser Asn Leu Thr Lys Leu Asp Ile 
    130                 135                 140                 


Ser Glu Asn Lys Ile Val Ile Leu Leu Asp Tyr Met Phe Gln Asp Leu 
145                 150                 155                 160 


Tyr Asn Leu Lys Ser Leu Glu Val Gly Asp Asn Asp Leu Val Tyr Ile 
                165                 170                 175     


Ser His Arg Ala Phe Ser Gly Leu Asn Ser Leu Glu Gln Leu Thr Leu 
            180                 185                 190         


Glu Lys Cys Asn Leu Thr Ser Ile Pro Thr Glu Ala Leu Ser His Leu 
        195                 200                 205             


His Gly Leu Ile Val Leu Arg Leu Arg His Leu Asn Ile Asn Ala Ile 
    210                 215                 220                 


Arg Asp Tyr Ser Phe Lys Arg Leu Tyr Arg Leu Lys Val Leu Glu Ile 
225                 230                 235                 240 


Ser His Trp Pro Tyr Leu Asp Thr Met Thr Pro Asn Cys Leu Tyr Gly 
                245                 250                 255     


Leu Asn Leu Thr Ser Leu Ser Ile Thr His Cys Asn Leu Thr Ala Val 
            260                 265                 270         


Pro Tyr Leu Ala Val Arg His Leu Val Tyr Leu Arg Phe Leu Asn Leu 
        275                 280                 285             


Ser Tyr Asn Pro Ile Ser Thr Ile Glu Gly Ser Met Leu His Glu Leu 
    290                 295                 300                 


Leu Arg Leu Gln Glu Ile Gln Leu Val Gly Gly Gln Leu Ala Val Val 
305                 310                 315                 320 


Glu Pro Tyr Ala Phe Arg Gly Leu Asn Tyr Leu Arg Val Leu Asn Val 
                325                 330                 335     


Ser Gly Asn Gln Leu Thr Thr Leu Glu Glu Ser Val Phe His Ser Val 
            340                 345                 350         


Gly Asn Leu Glu Thr Leu Ile Leu Asp Ser Asn Pro Leu Ala Cys Asp 
        355                 360                 365             


Cys Arg Leu Leu Trp Val Phe Arg Arg Arg Trp Arg Leu Asn Phe Asn 
    370                 375                 380                 


Arg Gln Gln Pro Thr Cys Ala Thr Pro Glu Phe Val Gln Gly Lys Glu 
385                 390                 395                 400 


Phe Lys Asp Phe Pro Asp Val Leu Leu Pro Asn Tyr Phe Thr Cys Arg 
                405                 410                 415     


Arg Ala Arg Ile Arg Asp Arg Lys Ala Gln Gln Val Phe Val Asp Glu 
            420                 425                 430         


Gly His Thr Val Gln Phe Val Cys Arg Ala Asp Gly Asp Pro Pro Pro 
        435                 440                 445             


Ala Ile Leu Trp Leu Ser Pro Arg Lys His Leu Val Ser Ala Lys Ser 
    450                 455                 460                 


Asn Gly Arg Leu Thr Val Phe Pro Asp Gly Thr Leu Glu Val Arg Tyr 
465                 470                 475                 480 


Ala Gln Val Gln Asp Asn Gly Thr Tyr Leu Cys Ile Ala Ala Asn Ala 
                485                 490                 495     


Gly Gly Asn Asp Ser Met Pro Ala His Leu His Val Arg Ser Tyr Ser 
            500                 505                 510         


Pro Asp Trp Pro His Gln Pro Asn Lys Thr Phe Ala Phe Ile Ser Asn 
        515                 520                 525             


Gln Pro Gly Glu Gly Glu Ala Asn Ser Thr Arg Ala Thr Val Pro Phe 
    530                 535                 540                 


Pro Phe Asp Ile Lys Thr Leu Ile Ile Ala Thr Thr Met Gly Phe Ile 
545                 550                 555                 560 


Ser Phe Leu Gly Val Val Leu Phe Cys Leu Val Leu Leu Phe Leu Trp 
                565                 570                 575     


Ser Arg Gly Lys Gly Asn Thr Lys His Asn Ile Glu Ile Glu Tyr Val 
            580                 585                 590         


Pro Arg Lys Ser Asp Ala Gly Ile Ser Ser Ala Asp Ala Pro Arg Lys 
        595                 600                 605             


Phe Asn Met Lys Met Ile 
    610                 


<210>  3
<211>  5608
<212>  DNA
<213>  Homo sapiens

<400>  3
aagacggatt ctcagacaag gcttgcaaat gccccgcagc catcatttaa ctgcacccgc     60

agaatagtta cggtttgtca cccgaccctc ccggatcgcc taatttgtcc ctagtgagac    120

cccgaggctc tgcccgcgcc tggcttcttc gtagctggat gcatatcgtg ctccgggcag    180

cgcgggcgca gggcacgcgt tcgcgcacac cctagcacac atgaacacgc gcaagagctg    240

aaccaagcac ggtttccatt tcaaaaaggg agacagcctc taccgcgatt gtagaagaga    300

ctgtggtgtg aattagggac cgggaggcgt cgaacggagg aacggttcat cttagagact    360

aattttctgg agtttctgcc cctgctctgc gtcagccctc acgtcacttc gccagcagta    420

gcagaggcgg cggcggcggc tcccggaatt gggttggagc aggagcctcg ctggctgctt    480

cgctcgcgct ctacgcgctc agtccccggc ggtagcagga gcctggaccc aggcgccgcc    540

ggcgggcgtg aggcgccgga gcccggcctc gaggtgcata ccggaccccc attcgcatct    600

aacaaggaat ctgcgcccca gagagtcccg ggagcgccgc cggtcggtgc ccggcgcgcc    660

gggccatgca gcgacggccg ccgcggagct ccgagcagcg gtagcgcccc cctgtaaagc    720

ggttcgctat gccggggcca ctgtgaaccc tgccgcctgc cggaacactc ttcgctccgg    780

accagctcag cctctgataa gctggactcg gcacgcccgc aacaagcacc gaggagttaa    840

gagagccgca agcgcaggga aggcctcccc gcacgggtgg gggaaagcgg ccggtgcagc    900

gcggggacag gcactcgggc tggcactggc tgctagggat gtcgtcctgg ataaggtggc    960

atggacccgc catggcgcgg ctctggggct tctgctggct ggttgtgggc ttctggaggg   1020

ccgctttcgc ctgtcccacg tcctgcaaat gcagtgcctc tcggatctgg tgcagcgacc   1080

cttctcctgg catcgtggca tttccgagat tggagcctaa cagtgtagat cctgagaaca   1140

tcaccgaaat tttcatcgca aaccagaaaa ggttagaaat catcaacgaa gatgatgttg   1200

aagcttatgt gggactgaga aatctgacaa ttgtggattc tggattaaaa tttgtggctc   1260

ataaagcatt tctgaaaaac agcaacctgc agcacatcaa ttttacccga aacaaactga   1320

cgagtttgtc taggaaacat ttccgtcacc ttgacttgtc tgaactgatc ctggtgggca   1380

atccatttac atgctcctgt gacattatgt ggatcaagac tctccaagag gctaaatcca   1440

gtccagacac tcaggatttg tactgcctga atgaaagcag caagaatatt cccctggcaa   1500

acctgcagat acccaattgt ggtttgccat ctgcaaatct ggccgcacct aacctcactg   1560

tggaggaagg aaagtctatc acattatcct gtagtgtggc aggtgatccg gttcctaata   1620

tgtattggga tgttggtaac ctggtttcca aacatatgaa tgaaacaagc cacacacagg   1680

gctccttaag gataactaac atttcatccg atgacagtgg gaagcagatc tcttgtgtgg   1740

cggaaaatct tgtaggagaa gatcaagatt ctgtcaacct cactgtgcat tttgcaccaa   1800

ctatcacatt tctcgaatct ccaacctcag accaccactg gtgcattcca ttcactgtga   1860

aaggcaaccc caaaccagcg cttcagtggt tctataacgg ggcaatattg aatgagtcca   1920

aatacatctg tactaaaata catgttacca atcacacgga gtaccacggc tgcctccagc   1980

tggataatcc cactcacatg aacaatgggg actacactct aatagccaag aatgagtatg   2040

ggaaggatga gaaacagatt tctgctcact tcatgggctg gcctggaatt gacgatggtg   2100

caaacccaaa ttatcctgat gtaatttatg aagattatgg aactgcagcg aatgacatcg   2160

gggacaccac gaacagaagt aatgaaatcc cttccacaga cgtcactgat aaaaccggtc   2220

gggaacatct ctcggtctat gctgtggtgg tgattgcgtc tgtggtggga ttttgccttt   2280

tggtaatgct gtttctgctt aagttggcaa gacactccaa gtttggcatg aaagatttct   2340

catggtttgg atttgggaaa gtaaaatcaa gacaaggtgt tggcccagcc tccgttatca   2400

gcaatgatga tgactctgcc agcccactcc atcacatctc caatgggagt aacactccat   2460

cttcttcgga aggtggccca gatgctgtca ttattggaat gaccaagatc cctgtcattg   2520

aaaatcccca gtactttggc atcaccaaca gtcagctcaa gccagacaca tttgttcagc   2580

acatcaagcg acataacatt gttctgaaaa gggagctagg cgaaggagcc tttggaaaag   2640

tgttcctagc tgaatgctat aacctctgtc ctgagcagga caagatcttg gtggcagtga   2700

agaccctgaa ggatgccagt gacaatgcac gcaaggactt ccaccgtgag gccgagctcc   2760

tgaccaacct ccagcatgag cacatcgtca agttctatgg cgtctgcgtg gagggcgacc   2820

ccctcatcat ggtctttgag tacatgaagc atggggacct caacaagttc ctcagggcac   2880

acggccctga tgccgtgctg atggctgagg gcaacccgcc cacggaactg acgcagtcgc   2940

agatgctgca tatagcccag cagatcgccg cgggcatggt ctacctggcg tcccagcact   3000

tcgtgcaccg cgatttggcc accaggaact gcctggtcgg ggagaacttg ctggtgaaaa   3060

tcggggactt tgggatgtcc cgggacgtgt acagcactga ctactacagg gtcggtggcc   3120

acacaatgct gcccattcgc tggatgcctc cagagagcat catgtacagg aaattcacga   3180

cggaaagcga cgtctggagc ctgggggtcg tgttgtggga gattttcacc tatggcaaac   3240

agccctggta ccagctgtca aacaatgagg tgatagagtg tatcactcag ggccgagtcc   3300

tgcagcgacc ccgcacgtgc ccccaggagg tgtatgagct gatgctgggg tgctggcagc   3360

gagagcccca catgaggaag aacatcaagg gcatccatac cctccttcag aacttggcca   3420

aggcatctcc ggtctacctg gacattctag gctagggccc ttttccccag accgatcctt   3480

cccaacgtac tcctcagacg ggctgagagg atgaacatct tttaactgcc gctggaggcc   3540

accaagctgc tctccttcac tctgacagta ttaacatcaa agactccgag aagctctcga   3600

gggaagcagt gtgtacttct tcatccatag acacagtatt gacttctttt tggcattatc   3660

tctttctctc tttccatctc ccttggttgt tcctttttct ttttttaaat tttctttttc   3720

tttttttttt cgtcttccct gcttcacgat tcttaccctt tcttttgaat caatctggct   3780

tctgcattac tattaactct gcatagacaa aggccttaac aaacgtaatt tgttatatca   3840

gcagacactc cagtttgccc accacaacta acaatgcctt gttgtattcc tgcctttgat   3900

gtggatgaaa aaaagggaaa acaaatattt cacttaaact ttgtcacttc tgctgtacag   3960

atatcgagag tttctatgga ttcacttcta tttatttatt attattactg ttcttattgt   4020

ttttggatgg cttaagcctg tgtataaaaa agaaaacttg tgttcaatct gtgaagcctt   4080

tatctatggg agattaaaac cagagagaaa gaagatttat tatgaaccgc aatatgggag   4140

gaacaaagac aaccactggg atcagctggt gtcagtccct acttaggaaa tactcagcaa   4200

ctgttagctg ggaagaatgt attcggcacc ttcccctgag gacctttctg aggagtaaaa   4260

agactactgg cctctgtgcc atggatgatt cttttcccat caccagaaat gatagcgtgc   4320

agtagagagc aaagatggct tccgtgagac acaagatggc gcatagtgtg ctcggacaca   4380

gttttgtctt cgtaggttgt gatgatagca ctggtttgtt tctcaagcgc tatccacaga   4440

acctttgtca acttcagttg aaaagaggtg gattcatgtc cagagctcat ttcggggtca   4500

ggtgggaaag ccaagaactt ggaaaagata agacaagcta taaattcgga ggcaagtttc   4560

ttttacaatg aacttttcag atctcacttc cctccgaccc ctaacttcca tgcccacccg   4620

tccttttaac tgtgcaagca aaattgtgca tggtcttcgt cgattaatac cttgtgtgca   4680

gacactactg ctccagacgt cgtttccctg ataggtagag cagatccata aaaaggtatg   4740

acttatacaa ttaggggaag ctaatggagt ttattagctg agtatcaatg tctctgcgtt   4800

gtacggtggt gatgggtttt aatgaatatg gaccctgaag cctggaaatc ctcatccacg   4860

tcgaacccac aggactgtgg gaagggcaga atcaatccct aagggaaagg aaacctcacc   4920

ctgagggcat cacatgcact catgttcagt gtacacaggt caagtccctt gctctgggct   4980

ctagttggga gagtggtttc attccaagtg tactccattg tcagtatgct gtttttgttt   5040

ccttcactcc attcaaaaag tcaaaataca aaatttggca cagcatgcca acgggaggct   5100

gtgcccagac caagcactgg aagtgtgctt ctaggcatag tcattggttt tgcaaaaaga   5160

gggctcaaat ttaaatagaa atttacagct atttgaatgg tcagatatac caagaaagaa   5220

aaatatttct gttcctcaag aaaacttgct accctctgtg aggggaattt tgctaaactt   5280

gacatcttta taacatgagc cagattgaaa gggagtgatt ttcattcatc ttaggtcatg   5340

ttatttcata tttgtttctg aaggtgcgat agctctgttt taggttttgc ttgcgcctgt   5400

taattactgg aacaccttat ttttcattaa aggctttgaa agccaattct caaaaattca   5460

aaagtgcaaa ttaacagaac aaaaggaaat ccagtagcaa ctgcagtcaa gcgagggagt   5520

tgacaagata aaccttacgt ccattcaagt tatatgctgg cctatgagag atgagagttg   5580

ggtcgtttgt tctctttgtt gatgattt                                      5608 


<210>  4
<211>  838
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Asp Phe Ser Trp Phe Gly Phe Gly Lys Val Lys Ser Arg Gln Gly 
465                 470                 475                 480 


Val Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
                485                 490                 495     


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
            500                 505                 510         


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
        515                 520                 525             


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
    530                 535                 540                 


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
545                 550                 555                 560 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
                565                 570                 575     


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
            580                 585                 590         


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
        595                 600                 605             


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
    610                 615                 620                 


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
625                 630                 635                 640 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
                645                 650                 655     


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
            660                 665                 670         


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
        675                 680                 685             


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
    690                 695                 700                 


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
705                 710                 715                 720 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
                725                 730                 735     


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
            740                 745                 750         


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
        755                 760                 765             


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
    770                 775                 780                 


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
785                 790                 795                 800 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
                805                 810                 815     


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
            820                 825                 830         


Tyr Leu Asp Ile Leu Gly 
        835             


<210>  5
<211>  4757
<212>  DNA
<213>  Rattus sp.

<400>  5
atctgtgtgc gagtgcgtgt gcgtgcgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     60

gtgtgagcgt gtgtgttttt ggatttcata ctaattttct ggagtttctg cccctgctct    120

gcgtcagccc tcacgtcact tcgccagcag tagcagaggc ggcggcggcc gccggttaga    180

gcccagtcgc tgcttcagct gctgttgctg cttctgcggc gctctgctcc ctgcgctggc    240

tacgggaggc cgggggagcc gcgccgacag tcctctgtgg ccagggccgg cactgtcctg    300

ctaccgcagt tgctccccag ccctgaggtg cgcaccgata tcgatatccg tgccggttta    360

gcggttctgc gacccaaaga gtccagggag agccaccgag tggcgcctgg cgtataggac    420

catgcagccg ccttgtggct tggagcagcg gcccgtgatg ttccagccac tgtgaaccat    480

ttggtcagcg ccaacctgct cagccccagc accgacaggc tcagcctctg gtacgctcct    540

ctcggcggga ggccatcagc accaagcagc aagagggctc agggaaggcc tcccccctcc    600

ggcgggggac gcctggctca gcgtagggac acgcactctg actgactggc actggcagct    660

cgggatgtcg ccctggccga ggtggcatgg acccgccatg gcgcggctct ggggcttatg    720

cttgctggtc ttgggcttct ggagggcttc tcttgcctgc cccatgtcct gcaaatgcag    780

caccactagg atttggtgta ccgagccttc tcctggcatc gtggcatttc cgaggttgga    840

acctaacagc attgacccag agaacatcac cgaaattctc attgcaaacc agaaaaggtt    900

agaaatcatc aatgaagatg atgtcgaagc ttacgtgggg ctgaaaaacc ttacaattgt    960

ggattccggc ttaaagtttg tggcttacaa ggcgtttctg aagaacggca acctgcggca   1020

catcaatttc actcgaaaca agctgacgag tttgtccagg agacatttcc gccaccttga   1080

cttgtctgac ctgatcctga cgggtaatcc gttcacgtgt tcctgtgaca tcatgtggct   1140

caagactctc caggagacga aatccagccc cgacactcag gatttgtatt gcctcaatga   1200

gagcagcaag aatacccctc tggcgaacct gcagattccc aattgtggtc tgccgtctgc   1260

acgtctggcc gctcctaacc tcacggtgga ggaagggaag tctgtgacca tttcctgcag   1320

cgtcgggggt gacccgctcc ccaccttgta ctgggacgtt gggaatttgg tttccaaaca   1380

catgaatgaa acaagccaca cacagggctc cttaaggata acaaacattt catcggatga   1440

cagtgggaaa caaatctctt gtgtggcaga aaacctcgtc ggagaagatc aagactctgt   1500

gaacctcact gtgcattttg caccaaccat cacatttctc gaatctccaa cctcagacca   1560

ccactggtgc atcccattca ctgtgagagg caaccccaag ccagcacttc agtggttcta   1620

caacggagcc atactgaatg aatccaagta catctgtacc aaaatacacg tcaccaatca   1680

cacggagtac cacggctgcc tccagctgga taaccccact catatgaata atggagacta   1740

caccctaatg gccaagaatg aatatgggaa ggacgagaga cagatttctg ctcacttcat   1800

gggccggcct ggagttgact atgagacaaa cccaaattac cctgaagtcc tctatgaaga   1860

ctggaccacg ccaactgaca tcggggatac tacaaacaaa agtaatgaga tcccctccac   1920

ggatgttgct gaccaaacca atcgggagca tctctcggtc tatgctgtgg tggtgattgc   1980

ctctgtggta ggattctgcc tgctggtgat gctgcttctg ctcaagttgg cgagacattc   2040

caagtttggc atgaaaggcc cagcttccgt catcagcaac gacgatgact ctgccagccc   2100

tctccaccac atctccaacg ggagcaacac tccgtcttct tcggagggcg ggcccgatgc   2160

tgtcatcatt gggatgacca agatccctgt cattgaaaac ccccagtact tcggtatcac   2220

caacagccag ctcaagccgg acacatttgt tcagcacatc aagagacaca acatcgttct   2280

gaagagggag cttggagaag gagcctttgg gaaagttttc ctagcggagt gctataacct   2340

ctgccccgag caggataaga tcctggtggc cgtgaagacg ctgaaggacg ccagcgacaa   2400

tgctcgcaag gactttcatc gcgaagccga gctgctgacc aacctccagc acgagcacat   2460

tgtcaagttc tacggtgtct gtgtggaggg cgacccactc atcatggtct ttgagtacat   2520

gaagcacggg gacctcaaca agttccttag ggcacacggg ccagatgcag tgctgatggc   2580

agagggtaac ccgcccaccg agctgacgca gtcgcagatg ctgcacatcg ctcagcaaat   2640

cgcagcaggc atggtctacc tggcatccca acacttcgtg caccgagacc tggccacccg   2700

gaactgcttg gtaggagaga acctgctggt gaaaattggg gacttcggga tgtcccggga   2760

tgtatacagc accgactact accgggttgg tggccacaca atgttgccca tccgatggat   2820

gcctccagag agcatcatgt acaggaaatt caccaccgag agtgacgtct ggagcctggg   2880

agttgtgttg tgggagatct tcacctacgg caagcagccc tggtatcagc tatcaaacaa   2940

cgaggtgata gaatgcatca cccagggcag agtccttcag cggcctcgca cgtgtcccca   3000

ggaggtgtac gagctgatgc tgggatgctg gcagcgggaa ccacacacaa ggaagaacat   3060

caagaacatc cacacactcc ttcagaactt ggcgaaggcg tcgcccgtct acctggacat   3120

cctaggctag actccctctt ctcccagacg gcccttccca aggcacccct cagacctctt   3180

aactgccgct gatgtcacca ccttgctgtc cttcgctctg acagtgttaa caagacaagg   3240

agcggctctc cggggtgagg cagtgcgcac ttccccatcc acagacagta tcgactcgct   3300

tctggctttg tcgctttctc tccctttggt ttgtttcttt cttttgccca ttctccattt   3360

atttatttat ttatttattt atttatttat ttatttattt atttatctat ctatctatct   3420

atttatttat ttatttattg gtcttcactg cttcatggtc ctcggcctct ctccttgacc   3480

gatctggctt ctgtactcct attcactgta catagacaaa ggccttaaca aacctgattt   3540

gttatatcag cagacactcc agtttgccca ccacaactaa caatgccttg ttgtattcct   3600

gcctttgatg tggatgaaaa aaagggaaaa aaaataatca aacatctgac ttaaaccgtc   3660

acttccgatg tacagacacg gggcgtttct atggattcac ttctatctat ctatttattt   3720

atttatctat ttatttattt ctcttctttg ttgttttccg gtggttttag cctgtgtatg   3780

agaagggaaa gtcatgtaca gtctgggaaa actttatctg tgggaaatgg aaaccagaag   3840

gggaaagaag ctttaccata aagcacagca ggagtgagac acagaaaagc cattggatca   3900

gccagagtcc gtcctgcata ggaaaaccca gcagccatca ggctggagga tcatgttcgg   3960

cactgacccc cgaggacctt tctgaggagg acacagaatg ttaaactctg catcatggac   4020

acagtttccg atcacagata ctggccttca atggaaaaaa aaaaaaaaaa aacccagata   4080

gttcttgtga gacctggaca gcacgtccaa catccagaca ttgtggtcgg gcacagtgac   4140

agagttgatg catttctcac gggttattct acagagcttt tgtcaagtcc aatggaagga   4200

ggtagattct tgttcagata tgatttcggg aaaaaccgag tccttgacaa agacaggaga   4260

caccctcagt tgggaggcaa gtttctctta ccttggactt tctcacacag caattctcac   4320

ccccaccccc tccactctca cctgtcttgt aactgtgcaa acaaaagtgt gcatggtctt   4380

tgtcagttga tacctttgtg cacctctgtg cagaaactgc tgtctgtccc ggctgtggta   4440

cccgatcagt ggggtagatc cacgaaaggt ctcattttag gccgctttgg gaaggtaacc   4500

agatcggtag ctggaagcac tctccagtag gtggcgaagg gtgagtgggt ctgctgaagc   4560

ctgcatatct tcacccacct caaacccacc gggctgcaca ggggacaggc acaggccacc   4620

cctgagggac agggaagctc tcttgggata ccacctgagt ttacattcag tgtgctcagg   4680

tcaagtctct cgctcggggc tctgtttcgg ggagaatggt ttcattccaa cgcactcatt   4740

atcaggattc tgttttc                                                  4757


<210>  6
<211>  821
<212>  PRT
<213>  Rattus sp.

<400>  6

Met Ser Pro Trp Pro Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Leu Cys Leu Leu Val Leu Gly Phe Trp Arg Ala Ser Leu Ala Cys 
            20                  25                  30          


Pro Met Ser Cys Lys Cys Ser Thr Thr Arg Ile Trp Cys Thr Glu Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Ile Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Leu Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Lys Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala Tyr Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Gly Asn Leu Arg His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Arg His Phe Arg His Leu Asp Leu Ser Asp Leu Ile 
    130                 135                 140                 


Leu Thr Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Leu Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Thr Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Thr Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Arg Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Val Thr Ile Ser Cys Ser Val Gly Gly Asp Pro 
    210                 215                 220                 


Leu Pro Thr Leu Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Arg Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Met Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Arg Gln Ile Ser Ala His Phe Met Gly Arg Pro Gly Val 
    370                 375                 380                 


Asp Tyr Glu Thr Asn Pro Asn Tyr Pro Glu Val Leu Tyr Glu Asp Trp 
385                 390                 395                 400 


Thr Thr Pro Thr Asp Ile Gly Asp Thr Thr Asn Lys Ser Asn Glu Ile 
                405                 410                 415     


Pro Ser Thr Asp Val Ala Asp Gln Thr Asn Arg Glu His Leu Ser Val 
            420                 425                 430         


Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu Val 
        435                 440                 445             


Met Leu Leu Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met Lys 
    450                 455                 460                 


Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro Leu 
465                 470                 475                 480 


His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly Gly 
                485                 490                 495     


Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu Asn 
            500                 505                 510         


Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr Phe 
        515                 520                 525             


Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu Gly 
    530                 535                 540                 


Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu Cys 
545                 550                 555                 560 


Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp Ala 
                565                 570                 575     


Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu Thr 
            580                 585                 590         


Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val Glu 
        595                 600                 605             


Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp Leu 
    610                 615                 620                 


Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala Glu 
625                 630                 635                 640 


Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile Ala 
                645                 650                 655     


Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe Val 
            660                 665                 670         


His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu Leu 
        675                 680                 685             


Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr Asp 
    690                 695                 700                 


Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met Pro 
705                 710                 715                 720 


Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val Trp 
                725                 730                 735     


Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro 
            740                 745                 750         


Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln Gly 
        755                 760                 765             


Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu Leu 
    770                 775                 780                 


Met Leu Gly Cys Trp Gln Arg Glu Pro His Thr Arg Lys Asn Ile Lys 
785                 790                 795                 800 


Asn Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val Tyr 
                805                 810                 815     


Leu Asp Ile Leu Gly 
            820     


<210>  7
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Val Ser Lys Arg 
1               5       


<210>  8
<211>  116
<212>  PRT
<213>  Unknown

<220>
<223>  VH Sequence of the 1A7 antibody

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Thr Glu Asp Phe 
    50                  55                  60                  


Gln Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Phe Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Val His Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  106
<212>  PRT
<213>  Unknown

<220>
<223>  VL Sequence of the IA7 antibody

<400>  9

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  10
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR1 sequence of the 1A7 antibody

<400>  10

Asn Tyr Gly Met Asn 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR2 sequence of the 1A7 antibody

<400>  11

Trp Ile Asn Thr Asp Thr Gly Glu Pro Thr Tyr Thr Glu Asp Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR3 sequence of the 1A7 antibody

<400>  12

Glu Gly Val His Phe Asp Tyr 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR1 sequence of the 1A7 antibody

<400>  13

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  14
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR2 sequence of the 1A7 antibody

<400>  14

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR3 sequence of the 1A7 antibody

<400>  15

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  16
<211>  120
<212>  PRT
<213>  Unknown

<220>
<223>  VH Sequence of the 3B5 antibody

<400>  16

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Tyr Tyr Gly Ser His Trp Phe Phe Asp Val Trp Gly Thr 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  17
<211>  106
<212>  PRT
<213>  Unknown

<220>
<223>  VL Sequence of the 3B5 antibody

<400>  17

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Arg Val Ser Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Leu Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Gly Gly Asn 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Thr Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  18
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR1 sequence of the 3B5 antibody

<400>  18

Ser Tyr Trp Met His 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR2 sequence of the 3B5 antibody

<400>  19

Val Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR3 sequence of the 3B5 antibody

<400>  20

Pro Tyr Tyr Gly Ser His Trp Phe Phe Asp 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR1 sequence of the 3B5 antibody

<400>  21

Ser Ala Ser Ser Arg Val Ser Tyr Val His 
1               5                   10  


<210>  22
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR2 sequence of the 3B5 antibody

<400>  22

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR3 sequence of the 3B5 antibody

<400>  23

Gln Gln Trp Ser Thr Asn Pro Pro Thr 
1               5                   


<210>  24
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  VH Sequence of the LI33 antibody

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Pro Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Gly Pro Ser Gly Gly Ile Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly His Asn Asp Trp Tyr Phe Asp Leu Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  VL Sequence of the LI33 antibody

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Lys Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR1 sequence of the LI33 antibody

<400>  26

Ile Tyr Pro Met Phe 
1               5   


<210>  27
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR2 sequence of the LI33 antibody

<400>  27

Trp Ile Gly Pro Ser Gly Gly Ile Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  VH CDR3 sequence of the LI33 antibody

<400>  28

Glu Gly His Asn Asp Trp Tyr Phe Asp Leu 
1               5                   10  


<210>  29
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR1 sequence of the LI33 antibody

<400>  29

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR2 sequence of the LI33 antibody

<400>  30

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  VL CDR3 sequence of the LI33 antibody

<400>  31

Gln Gln Tyr Asp Lys Trp Pro Leu Thr 
1               5                   


<210>  32
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic general structure for an oligonucleotide used in 
       preparation of siRNA molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, g, c, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  32
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  33
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic general structure for an oligonucleotide used in 
       preparation of siRNA molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, g, c, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  33
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  34
<211>  55
<212>  RNA
<213>  Unknown

<220>
<223>  shRNA sequence of LINGO-1 antagonist polynucleotide

<400>  34
ugaucgucau ccugcuagac uucaagagag ucuagcagga ugacgaucuu uuuuc          55


